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Senior Scientist, Cell Therapy Analytical Development

Sangamo BioSciences, Inc.

This is a Contract position in Brisbane, CA posted September 20, 2020.

Manager: Associate Director, Cell Therapy PD

Department: Cell Therapy Technical Development

Location: Brisbane, CA


Sangamo Therapeutics is seeking a Senior Scientist who will be responsible for the design, execution, analysis, and communication of process studies to understand the impact of process parameters on the quality of cellular products. This role requires a good understanding of the process environment and its impact on the function and activity of biological product quality attributes. A successful candidate will be able to independently develop flow cytometry panels, cell viability/vitality assays, functional assays, and cell characterization assays. The candidate will perform in cross functional project teams to develop robust and consistent cell manufacturing processes.


– Lead in design, development, and execution of in-process assays to aid in optimization of cell manufacturing processes
– Develop robust GMP release assays for cell therapy programs
– Transfer methods and training to QC staff
– Provide process analytical expertise in the areas of phenotypic analysis, genomics/proteomics, and cellular assays that indicate functionality and cell characterization
– Works effectively with research, manufacturing, quality, and analytical development teams
– Applies knowledge of stem cell and immune cell biology to establish process robustness
– Provide technical mentorship and development opportunities to junior staff
– Perform data analysis using statistical methods and knowledge systems
– Oversee the management and development of direct reports

– Ph.D. in Immunology, BioChemical Engineering, Cell Biology, Biological Sciences, or Biochemistry with 8+ years of experience in biotech/pharma industry
– Experience with:
– Stem and Immune cells (T cells, B Cells, NK cells, iPSCs, HSCs, etc.)
– Cell based assays, immunoassays, FACS analysis, primary cell characterization, differentiation assays
– Western blots, ddPCR, multi-panel Flow cytometry, colony forming assays
– Technology transfer
– Must have a solid understanding of manufacturing of cellular therapies including cell separation, cell processing, gene editing, and cell culture techniques for primary cells and stem cells
– Relevant skills include experience with immunological techniques (multi-panel flow cytometry, intracellular staining, cytotoxicity assays, ELISA, etc.) and molecular biology techniques (ddPCR, RT-PCR, mRNA and DNA prep)
– Excellent organizational, written communication and oral communication skills
– Ability to train and mentor scientists and research associates

Sangamo is an equal opportunity employer

The above reflects management’s definition of essential functions for this position but does not restrict the tasks that may be assigned.The above duties are representative only; management may assign or reassign duties and responsibilities to this position at any time.


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